The birth of the Cascina hamlet occurred in the middle ages at the same time as the construction of the ancient Roman Santa Maria parish church. The edifice was built at the end of the 11th century and the building has a layout similar to that of other basilicas: three naves, divided by monolithic columns in marble, pink granite and cipolin marble, characterized by Corinthian capital.
The main characteristic of the façade is the partition in five arches and alternating rhomboidal steps and three portals. The higher part of the façade is enriched by marble decorations and small arcading. At the centre of the gable, there is a marble cross with two oeil-de-boeufs on either side. Among the noteworthy artworks inside the church are a terracotta work by Bernardo da Maiano of the Madonna with child, a Romanic holy water stoup, and a 14th-century fresco.